THE HU LAB

2021

Hu, K. The Art of the Steal. Nature Microbiology 6, 421–422 (News and Views)

 

Hailing Zong, Mark Hazelbaker, Christina Moe, Stephanie C. Ems-McClung, Ke Hu, and Claire E. Walczak "Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration" Molecular Biology of the Cell 2021 32:7, 590-604

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2020

Leung JM*, Nagayasu E.*, Y.-c. Hwang, P. Pierce, I. Phan, R. Stacy, J. M. Murray,  K. Hu “A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers” BMC Mol Cell Biology 21(1):8 (* Equal Contribution)

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2019

Jacqueline Leung*, Jun Liu*, Laura Wetzel, John M. Murray, Ke Hu. "Centrin2 from the human parasite Toxoplasma gondii is required for its invasion and intracellular replication" Journal of Cell Science  132: jcs228791 (* Equal Contribution)

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2018

Yulia Pivovarova, Jun Liu, Johannes Lesigang, Oliver Koldyka, Rene Rauschmeier, Ke Hu* and Gang Dong*. "Structure of a novel dimeric set domain methyltransferase that regulates cell motility" Journal of Molecular Biology, S0022-2836(18)30422-4. (* Equal Contribution)

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2017

Jacqueline M. Leung, Yudou He, Fangliang Zhang, Yu-Chen Hwang, Eiji Nagayasu, Jun Liu, John M. Murray, Ke Hu "Stability and function of a putative microtubule organizing center in the human parasite Toxoplasma gondii"  Molecular Biology of the Cell E17-01-0045 (Featured on Cover of Journal)

Rachel Stadler, Lauren White, Ke Hu, Brian Helmke, William Guilford "Direct measurement of cortical force generation and polarization in a living parasite" Molecular Biology of the Cell, doi: 10.1091/mbc.E16-07-0518 (Selected for the special issue “Forces On and Within Cells”)

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John M. Murray “An icosahedral virus as a fluorescent calibration standard: a method for counting protein molecules in cells by fluorescence microscopy”  Journal of Microscopy, 267(2):193-213

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2016

Nagayasu, E., Y.-c. Hwang, J. Liu, J. Murray, and K. Hu, "Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host cell invasion." Molecular Biology of the Cell, 2016. 10.1091/mbc.E16-08-0587

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2015

J. Liu*, Y. He*, I. Benmerzouga, W. J. Sullivan Jr., N. S. Morrissette, J. M. Murray, K. Hu. “An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii” Molecular Biology of the Cell E15-11-0754. (2015) PMID:26680740 (Featured on cover of journal)(* Equal contributions)

2013

Senthilkumar Sivagurunathan, Aoife Heaslip, Jun Liu, Ke Hu. 2013. "Identification of functional modules of AKMT, a novel lysine methyltransferase regulating the motility of Toxoplasma gondii" Molecular & Biochemical Parasitology 189: 43–53.

 

Jun Liu, Laura Wetzel, Ying Zhang, Eiji Nagayasu, Stephanie Ems-McClung, Laurence Florens, Ke Hu. 2013. "Novel thioredoxin-like proteins are components of a protein complex coating the cortical microtubules of Toxoplasma gondii" Eukaryotic Cell 12(12):1588-99 (Featured on cover of journal)

 

2011

A.T. Heaslip, M. Nishi, B. Stein, K. Hu 2011. "The motility of a human protozoan parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase" PLoS Pathogens 7(9): e1002201 (Faculty of 1000 Selection)

 

2010

A.T. Heaslip, F. Dzierszinski, B. Stein, K. Hu 2010. "TgMORN1 is a key organizer of the basal complex in Toxoplasma gondii" PLoS Pathogens 6(2):e1000754

 

2009

A. T. Heaslip, S. C. Ems-McClung, K. Hu 2009. "TgICMAP1 is a novel microtubule binding protein in Toxoplasma gondii" PLoS One 4(10): e7406. doi:10.1371/journal.pone.0007406

 

2008

Natalia de Miguel, Maryse Lebrun, Aoife Heaslip, Ke Hu, Con J. Beckers, Mariana Matrajt, Jean François Dubremetz and Sergio O. Angel 2008. "Toxoplasma gondii Hsp20 is a stripe-arranged chaperone localized in the outer leaflet of the inner membrane complex" Biology of the Cell 100(8):479-89

 

Hu K 2008. "Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii" PLoS Pathogens 4(1): e10 doi:10.1371/journal.ppat.0040010

 

Manami Nishi, Ke Hu, John M. Murray, and David S. Roos 2008. "How to Build a Parasite: Organellar Dynamics during the Cell Cycle of Toxoplasma gondii" Journal of Cell Science 121:1559-1568

 

2007

Hu, K*., Ji L*., Applegate, K.T., Danuser G., Waterman-Storer C. 2007. "Differential Transmission of Actin Motion Within Focal Adhesions" Science 315:111-115. (Featured in "Editor's Choice" in Science: S. M. Hurtley, Cellular Mechanics Up Close and Personal. Sci. STKE 2007, tw15 (2007))(Faculty of 1000 Selection)(* Equal Contribution)

 

2006

K. Hu, J. Johnson, L. Florens, M. Fraunholz, S. Suravajjala, C. DiLullo, J. Yates, D. S. Roos and J. M. Murray 2006."Cytoskeletal components of an invasion machine – the apical complex of Toxoplasma gondii" (cover) PloS Pathogens, 2(2): 0121-0138 (Faculty of 1000 Selection)

 

Stacey D. Gilk, Yossef Raviv, Ke Hu, John Murray, Con J.M. Beckers, and Gary E. Ward 2006. "Identification of PhIL1, a Novel Cytoskeletal Protein of the Toxoplasma gondii Pellicle, through Photosensitized Labeling with 5-[125I]Iodonaphthalene-1-Azide" Eukaryotic Cell 5: 1611-1621

 

2004

K. Hu, D. S. Roos, S. O. Angel and J. M. Murray 2004. "Variability and heritability of cell division pathways in T. gondii" Journal of Cell Science 2004 117: 5697-5705

 

2003

D. M. Wetzel, S. Hakansson, K. Hu, D. Roos, and L. D. Sibley 2003. "Actin Filament Polymerization Propels Gliding Motility by Apicomplexan Parasites" Molec. Biol. Cell 14: 396-406

 

2002

Hu, K., T. Mann, B. Striepen, C.J. M. Beckers, D. S. Roos and J. M. Murray. 2002. "Daughter cell assembly in the protozoan parasite Toxoplasma gondii" Molec. Biol. Cell 13: 593-606.

 

Pelletier, L., Stern, A., Pypaert, M., Sheff, D., Ngo, H., Roper, N., He, C., Hu, K., Toomre, D., Coppens, I., Roos, D., Joiner, K and Warren, G 2002. "Golgi Biogenesis in Toxoplasma gondii" Nature 418, 548-552.

 

Swedlow, J.R., K. Hu, P.D. Andrews, D. S. Roos and J. M. Murray. 2002. "Measurement of tubulin content in the conoid and spindle pole of the parasite Toxoplasma gondii: A comparison of laser scanning confocal and wide field fluorescence microscopy for quantitative analysis in living cells" Proc. Nat'l Acad. Sci. USA 99:2014-2019.

 

Hu, K., D. S. Roos and J. M. Murray. 2002. "A novel polymer of tubulin forms the conoid in Toxoplasma gondii"(cover) J. Cell Biol. 156:1039-1050.